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Oozing from every line

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Day 2 of an E. coli bacteremia in ICU: the arterial line site oozes, venipuncture bruises spread, and the nurse reports blood in the ET tube secretions.

Results · trended

TestYesterdayToday 06:00TrendReference
Plt16846L150400 ×10⁹/L
INR1.11.9H0.91.1
aPTT3154H2535 s
Fib4.1H0.9LL1.54 g/L
Hb118L96L120160 g/L

Falling platelets AND falling fibrinogen AND prolonging times, in a septic patient. What is the diagnosis, and its central treatment?