Itching during the infusion

Ten minutes into her first dose of IV antibiotics, a 34-year-old is itching, flushed, and suddenly hoarse.

34-year-old womanWard 4, bed 2Fictitious educational patient

Pyelonephritis, day 1No known allergies (until now)

Day 1 · 14:10

The nurse pulls you in

The ceftriaxone infusion is ten minutes in. She is flushed, scratching hives on both forearms, her lips look fuller than they did at lunch, and her voice has gone tight. She says her chest feels 'like a belt'.

Vitals

HR118BP96/58RR24SpO294%T37.2

Examination

Airway: Voice hoarse; no stridor yet; lips and tongue edematous.
Chest: Scattered expiratory wheeze.
Skin: Urticaria over arms and trunk, flushing.

The infusion is stopped. What is the very next action?

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